所在学科专业：

免疫学

研究方向：

1. 肿瘤免疫

讲授课程：

本科生：

七年制《医学免疫学》实验课/理论课

五年制《医学免疫学》实验课

职工《Medical Immunology》实验课/理论课

研究生：

硕士《高级免疫学实验技术》

博士《高级免疫学理论与技术》实验课

教育经历：

2003.9-2007.7 必赢网址bwi437，免疫学系，医学博士

2001.9-2003.7 必赢网址bwi437，免疫学系，医学硕士

1995.9-2000.7 白求恩医科大学，临床医学二系，医学学士

工作经历：

2011.6-2012.5美国明尼苏达大学，医学院转化医学系 访问学者

2007.7-至今 必赢网址bwi437，437ccm必赢国际免疫学系讲师

2005.9-2007.6 必赢网址bwi437，437ccm必赢国际免疫学系 助教

科研项目：

1.吉林省“双十工程”重大科技攻关项目，20140201012YY，通用癌症疫苗—注射用重组MUC1-MBP融合蛋白制剂的临床前研究，2014/01-2016/12，150万，在研，主要参加人

学术论文：

发表文章（近三年，10篇以内）

1.Yuan H^#,Wang J^#, Wang F, Zhang N, Li Q, Xie F, Chen T, Zhai R, Wang F, Guo Y, Ni W, Tai G*., Mucin1 gene silencing inhibits the growth of human hepatoma SMMC-7721 cells through Bax mediated mitochondrial and caspase-8 mediated death receptor apoptotic pathways. Molecular Medicine Report, 2015(12): 6782-6788.

2. Wang J, Liu G, Li Q, Wang F, Xie F, Zhai R, Guo Y, Chen T, Zhang N, Ni W, Yuan H, Tai G*, Mucin1 promotes the migration and invasion of hepatocellularcarcinoma cells via JNK-mediated phosphorylation of Smad2 atthe C-terminal and linker regions, Oncotarget, 2015,6(22): 19264-19278.

3. Li Q, Liu G,Yuan H, Wang J, Guo Y, Chen T, Zhai R, Shao D, Ni W, Tai G*. Mucin1 shifts Smad3 signaling from the tumor-suppressive pSmad3C/p21WAF1 pathway to the oncogenic pSmad3L/c-Myc pathway by activating JNK in human hepatocellular carcinoma cells, Oncotarget, 2015(5):4253- 4265.

4. Li Q, Liu G, Shao D, Wang J,Yuan H, Chen T, Zhai R, Ni W, Tai G*,Mucin1 mediates autocrine transforming growth factor beta signaling through activating the c-Jun N-terminal kinase/activator protein 1 pathway in human hepatocellular carcinoma cells, The International Journal of Biochemistry & Cell Biology, 2015(59): 116-125.

5. Wang F^#, Ni W^#, Liu G, Wang J, Xie F,Yuan H, Guo Y, Zhai R, Chen T, Li Q, Tai G*. Escherichia coli maltose-binding protein (MBP) directly induces mouse Th1 activation through upregulating TLR2 and downregulating TLR4 expressions, Immunobiology, 2015, 220(6): 782-788.

6. Ni W, Zhang Q, Liu G, Wang F,Yuan H, Guo Y, Zhang X, Xie F, Li Q, Tai G*, Escherichia coli maltose binding protein activates mouse peritoneal macrophages and polarizes them into M1-type in vivo and in vitro, International Immunopharmacology, 2014 (21): 171-180.

7. Li Q^#, Wang F^#, Liu G, Yuan H, Chen T, Wang J, Xie F, Zhai R, Wang F, Guo Y, Ni W, Tai G*. Impact of mucin1 knockdown on the phenotypic characteristics of the human hepatocellular carcinoma cell line SMMC-7721, Oncology Reports, 2014(31): 2811- 2819.

8. Jia J, Yang M, Chen Y,Yuan H, Li J, Cui X, Liu Z, Inducing apoptosis effect of caffeic acid 3,4-dihydroxy-phenethyl ester on the breast cancer cells, Tumor Biology, 2014,35(12):11781-11789.

9. Koodie L,Yuan H, Pumper JA, Yu H, Charboneau R, Ramkrishnan S, Roy S*, Morphine inhibits migration of tumor-infiltrating leukocytes and suppresses angiogenesis associated with tumor growth in mice, American Journal of Pathology, 2014,184(4): 1073-1084.

著作教材：

1.《免疫学教程》 郭焱，李妍，许礼发主编.—北京：清华大学出版社，2015，参编

获奖情况：

无

社会兼职：

无